NAPRT


Summary: Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nicotinate phosphoribosyltransferaseMIM:611552Ensembl:ENSG00000147813HGNC:HGNC:30450PA1426712938q24.3

GO terms in NAPRT


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004514nicotinate-nucleotide diphosphorylase (carboxylating) activity
MFIBAGO:0004516nicotinate phosphoribosyltransferase activity
MFIDAGO:0004516nicotinate phosphoribosyltransferase activity
MFTASGO:0004516nicotinate phosphoribosyltransferase activity
MFIPIGO:0005515protein binding
BPIMPGO:0006979response to oxidative stress
BPIBAGO:0009435NAD biosynthetic process
BPIEAGO:0019358nicotinate nucleotide salvage
BPIBAGO:0034355NAD salvage
BPTASGO:0034356NAD biosynthesis via nicotinamide riboside salvage pathway
BPTASGO:0043312neutrophil degranulation
CCTASGO:0005576extracellular region
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0035578azurophil granule lumen
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: NAPRT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NAPRT


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-196807Nicotinate metabolism
reactomeR-HSA-196849Metabolism of water-soluble vitamins and cofactors
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-197264Nicotinamide salvaging
reactomeR-HSA-6798695Neutrophil degranulation
kegghsa00760Nicotinate and nicotinamide metabolism - Homo sapiens (human)
wikipathwaysWP3645NAD+ biosynthetic pathways

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD756GNE-6171

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NAPRT

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