NAT8
Summary: This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| N-acetyltransferase 8 (putative) | MIM:606716 | Ensembl:ENSG00000144035 | HGNC:HGNC:18069 | PA31450 | 2p13.1 |
Gene Categories:
DRUG RESISTANCEGO terms in NAT8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor |
| MF | TAS | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0047198 | cysteine-S-conjugate N-acetyltransferase activity |
| BP | IDA | GO:0006749 | glutathione metabolic process |
| BP | IEA | GO:0006749 | glutathione metabolic process |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0018003 | peptidyl-lysine N6-acetylation |
| BP | TAS | GO:0042493 | response to drug |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IMP | GO:0050435 | amyloid-beta metabolic process |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
Gene expression in normal tissue: NAT8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NAT8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-977225 | Amyloid fiber formation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NAT8
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.