NAT8


Summary: This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
N-acetyltransferase 8 (putative)MIM:606716Ensembl:ENSG00000144035HGNC:HGNC:18069PA314502p13.1

Gene Categories:

DRUG RESISTANCE

GO terms in NAT8


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
MFTASGO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
MFIPIGO:0005515protein binding
MFIDAGO:0047198cysteine-S-conjugate N-acetyltransferase activity
BPIDAGO:0006749glutathione metabolic process
BPIEAGO:0006749glutathione metabolic process
BPIMPGO:0010628positive regulation of gene expression
BPIDAGO:0018003peptidyl-lysine N6-acetylation
BPTASGO:0042493response to drug
BPIDAGO:0043066negative regulation of apoptotic process
BPTASGO:0044267cellular protein metabolic process
BPIMPGO:0050435amyloid-beta metabolic process
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005789endoplasmic reticulum membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005793endoplasmic reticulum-Golgi intermediate compartment
CCIDAGO:0016021integral component of membrane
CCIDAGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane

Gene expression in normal tissue: NAT8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NAT8


DatabasePathway IDPathway Des.
kegghsa00480Glutathione metabolism - Homo sapiens (human)
wikipathwaysWP702Metapathway biotransformation Phase I and II
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-977225Amyloid fiber formation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NAT8

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