NCAN
Summary: Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurocan | MIM:600826 | Ensembl:ENSG00000130287 | HGNC:HGNC:2465 | PA162396986 | 19p13.11 |
Gene Categories:
DRUGGABLE GENOMEGO terms in NCAN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0030246 | carbohydrate binding |
| BP | IBA | GO:0001501 | skeletal system development |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007417 | central nervous system development |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | TAS | GO:0030206 | chondroitin sulfate biosynthetic process |
| BP | TAS | GO:0030207 | chondroitin sulfate catabolic process |
| BP | TAS | GO:0030208 | dermatan sulfate biosynthetic process |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | TAS | GO:0043202 | lysosomal lumen |
Gene expression in normal tissue: NCAN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCAN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2431 | Spinal Cord Injury |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism |
| reactome | R-HSA-1971475 | A tetrasaccharide linker sequence is required for GAG synthesis |
| reactome | R-HSA-2022870 | Chondroitin sulfate biosynthesis |
| reactome | R-HSA-2022923 | Dermatan sulfate biosynthesis |
| reactome | R-HSA-2024101 | CS/DS degradation |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism |
| reactome | R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type |
| reactome | R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD |
| reactome | R-HSA-3595172 | Defective CHST3 causes SEDCJD |
| reactome | R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type |
| reactome | R-HSA-3595177 | Defective CHSY1 causes TPBS |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-419037 | NCAM1 interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCAN
CLASSFICATION
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