NCOA5
Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
nuclear receptor coactivator 5 | MIM:616825 | Ensembl:ENSG00000124160 | HGNC:HGNC:15909 | PA31474 | 20q13.12 |
GO terms in NCOA5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003682 | chromatin binding |
MF | HDA | GO:0003723 | RNA binding |
MF | IPI | GO:0005515 | protein binding |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
BP | IEA | GO:0042593 | glucose homeostasis |
BP | IEA | GO:0046627 | negative regulation of insulin receptor signaling pathway |
CC | HDA | GO:0005615 | extracellular space |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0015629 | actin cytoskeleton |
Gene expression in normal tissue: NCOA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCOA5
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in NCOA5