NECTIN2
Summary: This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nectin cell adhesion molecule 2 | MIM:600798 | Ensembl:ENSG00000130202 | HGNC:HGNC:9707 | PA34052 | 19q13.32 |
GO terms in NECTIN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015026 | coreceptor activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0050839 | cell adhesion molecule binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | ISS | GO:0005915 | zonula adherens |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0044291 | cell-cell contact zone |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001675 | acrosome assembly |
| BP | IMP | GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| BP | IMP | GO:0002891 | positive regulation of immunoglobulin mediated immune response |
| BP | IEA | GO:0007010 | cytoskeleton organization |
| BP | IDA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IEA | GO:0007165 | signal transduction |
| BP | ISS | GO:0007286 | spermatid development |
| BP | IEA | GO:0007289 | spermatid nucleus differentiation |
| BP | IEA | GO:0009566 | fertilization |
| BP | IDA | GO:0019064 | fusion of virus membrane with host plasma membrane |
| BP | IEA | GO:0030382 | sperm mitochondrion organization |
| BP | IEA | GO:0032990 | cell part morphogenesis |
| BP | IMP | GO:0033005 | positive regulation of mast cell activation |
| BP | TAS | GO:0034332 | adherens junction organization |
| BP | IMP | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity |
| BP | IDA | GO:0044406 | adhesion of symbiont to host |
| BP | IEA | GO:0044782 | cilium organization |
| BP | IMP | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
| BP | IDA | GO:0046596 | regulation of viral entry into host cell |
| BP | IDA | GO:0046814 | coreceptor-mediated virion attachment to host cell |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | IDA | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| BP | IEA | GO:0051654 | establishment of mitochondrion localization |
| BP | IDA | GO:0060370 | susceptibility to T cell mediated cytotoxicity |
Gene expression in normal tissue: NECTIN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NECTIN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-420597 | Nectin/Necl trans heterodimerization |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| wikipathways | WP727 | Monoamine Transport |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | nectin_pathway | Nectin adhesion pathway |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NECTIN2
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