Summary: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009].


GO terms in NFASC

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002175protein localization to paranode region of axon
BPIEAGO:0007411axon guidance
BPISSGO:0007422peripheral nervous system development
BPIEAGO:0019226transmission of nerve impulse
BPIEAGO:0030913paranodal junction assembly
BPIEAGO:0034113heterotypic cell-cell adhesion
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0045162clustering of voltage-gated sodium channels
BPIEAGO:0050808synapse organization
BPIEAGO:0071205protein localization to juxtaparanode region of axon
BPIEAGO:0072659protein localization to plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIEAGO:0016021integral component of membrane
CCIEAGO:0033010paranodal junction
CCISSGO:0033268node of Ranvier
CCTASGO:0033268node of Ranvier
CCIEAGO:0033270paranode region of axon
CCISSGO:0043194axon initial segment
CCIEAGO:0043209myelin sheath
CCIEAGO:0097454Schwann cell microvillus
CCTASGO:0101003ficolin-1-rich granule membrane
MFIPIGO:0005515protein binding
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0086080protein binding involved in heterotypic cell-cell adhesion

Gene expression in normal tissue: NFASC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NFASC

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-447043Neurofascin interactions
reactomeR-HSA-447043Neurofascin interactions
reactomeR-HSA-6798695Neutrophil degranulation
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NFASC