NISCH
Summary: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nischarin | MIM:615507 | Ensembl:ENSG00000010322 | HGNC:HGNC:18006 | PA31635 | 3p21.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in NISCH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005769 | early endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0055037 | recycling endosome |
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0008217 | regulation of blood pressure |
| BP | IEA | GO:0016601 | Rac protein signal transduction |
| BP | IEA | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0032228 | regulation of synaptic transmission, GABAergic |
| BP | IEA | GO:0048243 | norepinephrine secretion |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IBA | GO:0005200 | structural constituent of cytoskeleton |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: NISCH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NISCH
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NISCH
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