NOB1
Summary: In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIN1 (RPN12) binding protein 1 homolog | MIM:613586 | Ensembl:ENSG00000141101 | HGNC:HGNC:29540 | PA143485585 | 16q22.1 |
GO terms in NOB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006364 | rRNA processing |
| BP | IEA | GO:0007601 | visual perception |
| BP | IBA | GO:0030490 | maturation of SSU-rRNA |
| BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0030688 | preribosome, small subunit precursor |
| MF | EXP | GO:0004521 | endoribonuclease activity |
| MF | IBA | GO:0004521 | endoribonuclease activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: NOB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NOB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NOB1
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