Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008].

NOP10 ribonucleoproteinMIM:606471Ensembl:ENSG00000182117HGNC:HGNC:14378PA16472397315q14

GO terms in NOP10

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005697telomerase holoenzyme complex
CCTASGO:0005697telomerase holoenzyme complex
CCTASGO:0005732small nucleolar ribonucleoprotein complex
CCIDAGO:0016604nuclear body
CCIBAGO:0031429box H/ACA snoRNP complex
CCIDAGO:0031429box H/ACA snoRNP complex
CCTASGO:0031429box H/ACA snoRNP complex
CCTASGO:0072589box H/ACA scaRNP complex
CCIBAGO:0090661box H/ACA telomerase RNP complex
CCIDAGO:0090661box H/ACA telomerase RNP complex
CCTASGO:0090661box H/ACA telomerase RNP complex
BPIEAGO:0000454snoRNA guided rRNA pseudouridine synthesis
BPNASGO:0001522pseudouridine synthesis
BPTASGO:0007004telomere maintenance via telomerase
BPIBAGO:0031118rRNA pseudouridine synthesis
BPIBAGO:0031120snRNA pseudouridine synthesis
BPHMPGO:1904874positive regulation of telomerase RNA localization to Cajal body
MFIPIGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0034513box H/ACA snoRNA binding
MFIPIGO:0034513box H/ACA snoRNA binding
MFIBAGO:0070034telomerase RNA binding
MFIPIGO:0070034telomerase RNA binding
MFTASGO:0070034telomerase RNA binding

Gene expression in normal tissue: NOP10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NOP10

DatabasePathway IDPathway Des.
reactomeR-HSA-6790901rRNA modification in the nucleus and cytosol
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
kegghsa03008Ribosome biogenesis in eukaryotes - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NOP10