NPAS2


Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neuronal PAS domain protein 2MIM:603347Ensembl:ENSG00000170485HGNC:HGNC:7895PA316962q11.2

GO terms in NPAS2


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIPIGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0046983protein dimerization activity
MFIDAGO:0051879Hsp90 protein binding
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006974cellular response to DNA damage stimulus
BPTASGO:0007417central nervous system development
BPTASGO:0007623circadian rhythm
BPTASGO:0019216regulation of lipid metabolic process
BPISSGO:0032922circadian regulation of gene expression
BPIMPGO:0045739positive regulation of DNA repair
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0051775response to redox state
BPIMPGO:0060548negative regulation of cell death
BPIMPGO:2001020regulation of response to DNA damage stimulus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIPIGO:0005667transcription factor complex
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol

Gene expression in normal tissue: NPAS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NPAS2


DatabasePathway IDPathway Des.
kegghsa04710Circadian rhythm - Homo sapiens (human)
pidcircadianpathwayCircadian rhythm pathway
wikipathwaysWP1797Circadian Clock
wikipathwaysWP2797Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
wikipathwaysWP3370RORA activates gene expression
wikipathwaysWP3394NR1D1 (REV-ERBA) represses gene expression
reactomeR-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactomeR-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259014

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NPAS2

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