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NPAS2

Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
neuronal PAS domain protein 2	MIM:603347	Ensembl:ENSG00000170485	HGNC:HGNC:7895	PA31696	2q11.2

Gene Categories:

DNA REPAIR TRANSCRIPTION FACTOR COMPLEX

GO terms in NPAS2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	ISS	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0003677	DNA binding
MF	IPI	GO:0003677	DNA binding
MF	TAS	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0046872	metal ion binding
MF	IEA	GO:0046983	protein dimerization activity
MF	IDA	GO:0051879	Hsp90 protein binding
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006974	cellular response to DNA damage stimulus
BP	TAS	GO:0007417	central nervous system development
BP	TAS	GO:0007623	circadian rhythm
BP	TAS	GO:0019216	regulation of lipid metabolic process
BP	ISS	GO:0032922	circadian regulation of gene expression
BP	IMP	GO:0045739	positive regulation of DNA repair
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IMP	GO:0045893	positive regulation of transcription, DNA-templated
BP	IGI	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IDA	GO:0051775	response to redox state
BP	IMP	GO:0060548	negative regulation of cell death
BP	IMP	GO:2001020	regulation of response to DNA damage stimulus
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IPI	GO:0005667	transcription factor complex
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol

Gene expression in normal tissue: NPAS2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NPAS2

Database	Pathway ID	Pathway Des.
kegg	hsa04710	Circadian rhythm - Homo sapiens (human)
pid	circadianpathway	Circadian rhythm pathway
wikipathways	WP1797	Circadian Clock
wikipathways	WP2797	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
wikipathways	WP3370	RORA activates gene expression
wikipathways	WP3394	NR1D1 (REV-ERBA) represses gene expression
reactome	R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactome	R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1989781	PPARA activates gene expression
reactome	R-HSA-1989781	PPARA activates gene expression
reactome	R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactome	R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactome	R-HSA-400253	Circadian Clock
reactome	R-HSA-400253	Circadian Clock
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-556833	Metabolism of lipids

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NPAS2

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