NPAS2
Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
neuronal PAS domain protein 2 | MIM:603347 | Ensembl:ENSG00000170485 | HGNC:HGNC:7895 | PA31696 | 2q11.2 |
GO terms in NPAS2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ISS | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0003677 | DNA binding |
MF | IPI | GO:0003677 | DNA binding |
MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0046872 | metal ion binding |
MF | IEA | GO:0046983 | protein dimerization activity |
MF | IDA | GO:0051879 | Hsp90 protein binding |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
BP | TAS | GO:0007417 | central nervous system development |
BP | TAS | GO:0007623 | circadian rhythm |
BP | TAS | GO:0019216 | regulation of lipid metabolic process |
BP | ISS | GO:0032922 | circadian regulation of gene expression |
BP | IMP | GO:0045739 | positive regulation of DNA repair |
BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
BP | IDA | GO:0051775 | response to redox state |
BP | IMP | GO:0060548 | negative regulation of cell death |
BP | IMP | GO:2001020 | regulation of response to DNA damage stimulus |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IPI | GO:0005667 | transcription factor complex |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: NPAS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPAS2
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
pid | circadianpathway | Circadian rhythm pathway |
wikipathways | WP1797 | Circadian Clock |
wikipathways | WP2797 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
wikipathways | WP3370 | RORA activates gene expression |
wikipathways | WP3394 | NR1D1 (REV-ERBA) represses gene expression |
reactome | R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
reactome | R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1989781 | PPARA activates gene expression |
reactome | R-HSA-1989781 | PPARA activates gene expression |
reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
reactome | R-HSA-400253 | Circadian Clock |
reactome | R-HSA-400253 | Circadian Clock |
reactome | R-HSA-556833 | Metabolism of lipids |
reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPAS2