NPEPPS
Summary: This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aminopeptidase puromycin sensitive | MIM:606793 | Ensembl:ENSG00000141279 | HGNC:HGNC:7900 | PA31703 | 17q21.32 |
GO terms in NPEPPS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000209 | protein polyubiquitination |
| BP | IBA | GO:0006508 | proteolysis |
| BP | IBA | GO:0043171 | peptide catabolic process |
| BP | IDA | GO:0071456 | cellular response to hypoxia |
| BP | HMP | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | EXP | GO:0004177 | aminopeptidase activity |
| MF | IBA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0042277 | peptide binding |
| MF | IBA | GO:0070006 | metalloaminopeptidase activity |
Gene expression in normal tissue: NPEPPS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPEPPS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPEPPS
CLASSFICATION
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