NR1H3


Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor subfamily 1 group H member 3MIM:602423Ensembl:ENSG00000025434HGNC:HGNC:7966PA3175111p11.2

GO terms in NR1H3


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0043235receptor complex
CCIBAGO:0090575RNA polymerase II transcription factor complex
CCIDAGO:0090575RNA polymerase II transcription factor complex
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIBAGO:0006629lipid metabolic process
BPIBAGO:0007275multicellular organism development
BPICGO:0010745negative regulation of macrophage derived foam cell differentiation
BPIMPGO:0010867positive regulation of triglyceride biosynthetic process
BPIDAGO:0010870positive regulation of receptor biosynthetic process
BPIDAGO:0010875positive regulation of cholesterol efflux
BPIMPGO:0010875positive regulation of cholesterol efflux
BPIMPGO:0010887negative regulation of cholesterol storage
BPIBAGO:0030154cell differentiation
BPIEAGO:0030522intracellular receptor signaling pathway
BPIMPGO:0032270positive regulation of cellular protein metabolic process
BPIMPGO:0032369negative regulation of lipid transport
BPIDAGO:0032376positive regulation of cholesterol transport
BPIDAGO:0032570response to progesterone
BPIBAGO:0033993response to lipid
BPIDAGO:0034145positive regulation of toll-like receptor 4 signaling pathway
BPIBAGO:0042632cholesterol homeostasis
BPIDAGO:0042632cholesterol homeostasis
BPISSGO:0042632cholesterol homeostasis
BPTASGO:0042752regulation of circadian rhythm
BPISSGO:0043031negative regulation of macrophage activation
BPIMPGO:0043277apoptotic cell clearance
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIMPGO:0045723positive regulation of fatty acid biosynthetic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0048550negative regulation of pinocytosis
BPIBAGO:0050728negative regulation of inflammatory response
BPISSGO:0050728negative regulation of inflammatory response
BPIMPGO:0051006positive regulation of lipoprotein lipase activity
BPIBAGO:0055088lipid homeostasis
BPISSGO:0055088lipid homeostasis
BPISSGO:0055092sterol homeostasis
BPNASGO:0060336negative regulation of interferon-gamma-mediated signaling pathway
BPISSGO:0070328triglyceride homeostasis
BPIBAGO:0071222cellular response to lipopolysaccharide
BPIDAGO:0071222cellular response to lipopolysaccharide
BPISSGO:0090188negative regulation of pancreatic juice secretion
BPISSGO:0090341negative regulation of secretion of lysosomal enzymes
BPIDAGO:2000325regulation of nuclear receptor transcription coactivator activity
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFTASGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFIDAGO:0003713transcription coactivator activity
MFIBAGO:0004879nuclear receptor activity
MFTASGO:0004879nuclear receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0008289lipid binding
MFTASGO:0015485cholesterol binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0032810sterol response element binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIBAGO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding

Gene expression in normal tissue: NR1H3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NR1H3


DatabasePathway IDPathway Des.
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-4090294SUMOylation of intracellular receptors
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8866427VLDLR internalisation and degradation
reactomeR-HSA-8964043Plasma lipoprotein clearance
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP2011SREBF and miR33 in cholesterol and lipid homeostasis
wikipathwaysWP236Adipogenesis
wikipathwaysWP2874Liver X Receptor Pathway
wikipathwaysWP2878PPAR Alpha Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP299Nuclear Receptors in Lipid Metabolism and Toxicity
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP4011Steatosis AOP
wikipathwaysWP4149White fat cell differentiation
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD60Quinoclamine2
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib2
iGMDRD322FK 8662
iGMDRD100Zebularine2
iGMDRD398Sepantronium3
iGMDRD562Navitoclax3
iGMDRD577BIX012943
iGMDRD267Oligomycin A3
iGMDRD870BRD636102
iGMDRD481Dactolisib2
iGMDRD474Avrainvillamide2
iGMDRD137Indisulam2
iGMDRD121GMX17785
iGMDRD103SN-382
iGMDRD123Isoevodiamine3
iGMDRD466Chaetocin3
iGMDRD945ML2143
iGMDRD61Kinetin riboside5
iGMDRD152179324-69-73
iGMDRD351GW843682X3
iGMDRD427ABT7372
iGMDRD701NVP-AUY9222
iGMDRD599Salermide3
iGMDRD512nutlin 34

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR1H3

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