NT5E
Summary: The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 5'-nucleotidase ecto | MIM:129190 | Ensembl:ENSG00000135318 | HGNC:HGNC:8021 | PA31804 | 6q14.3 |
GO terms in NT5E
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000166 | nucleotide binding |
| MF | EXP | GO:0008253 | 5'-nucleotidase activity |
| MF | IDA | GO:0008253 | 5'-nucleotidase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0006195 | purine nucleotide catabolic process |
| BP | IEA | GO:0006196 | AMP catabolic process |
| BP | TAS | GO:0006259 | DNA metabolic process |
| BP | IDA | GO:0007159 | leukocyte cell-cell adhesion |
| BP | IEA | GO:0016311 | dephosphorylation |
| BP | TAS | GO:0019674 | NAD metabolic process |
| BP | IEA | GO:0046086 | adenosine biosynthetic process |
| BP | TAS | GO:0046135 | pyrimidine nucleoside catabolic process |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0031225 | anchored component of membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: NT5E
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NT5E
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-196807 | Nicotinate metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-73621 | Pyrimidine catabolism |
| reactome | R-HSA-74259 | Purine catabolism |
| reactome | R-HSA-8956319 | Nucleobase catabolism |
| pharmgkb | PA2040 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| humancyc | PWY-5695 | urate biosynthesis/inosine 5,-phosphate degradation |
| humancyc | PWY-6353 | purine nucleotides degradation |
| humancyc | SALVADEHYPOX-PWY | adenosine nucleotides degradation |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00760 | Nicotinate and nicotinamide metabolism - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP3644 | NAD+ metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NT5E
CLASSFICATION
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