NTMT1
Summary: The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
N-terminal Xaa-Pro-Lys N-methyltransferase 1 | MIM:613560 | Ensembl:ENSG00000148335 | HGNC:HGNC:23373 | PA162395788 | 9q34.11 |
Gene Categories:
HISTONE MODIFICATIONGO terms in NTMT1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0008168 | methyltransferase activity |
MF | IDA | GO:0008276 | protein methyltransferase activity |
MF | IDA | GO:0042054 | histone methyltransferase activity |
MF | IBA | GO:0071885 | N-terminal protein N-methyltransferase activity |
MF | IDA | GO:0071885 | N-terminal protein N-methyltransferase activity |
BP | IBA | GO:0006480 | N-terminal protein amino acid methylation |
BP | IMP | GO:0007051 | spindle organization |
BP | IMP | GO:0007059 | chromosome segregation |
BP | IDA | GO:0016571 | histone methylation |
BP | IBA | GO:0018011 | N-terminal peptidyl-alanine methylation |
BP | IEA | GO:0018012 | N-terminal peptidyl-alanine trimethylation |
BP | IDA | GO:0018013 | N-terminal peptidyl-glycine methylation |
BP | IDA | GO:0018016 | N-terminal peptidyl-proline dimethylation |
BP | IBA | GO:0035568 | N-terminal peptidyl-proline methylation |
BP | IBA | GO:0035570 | N-terminal peptidyl-serine methylation |
BP | IDA | GO:0035572 | N-terminal peptidyl-serine dimethylation |
BP | IDA | GO:0035573 | N-terminal peptidyl-serine trimethylation |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: NTMT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTMT1
Database | Pathway ID | Pathway Des. |
---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTMT1