NXF1


Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear RNA export factor 1MIM:602647Ensembl:ENSG00000162231HGNC:HGNC:8071PA3185811q12.3

Gene Categories:

TRANSPORTER

GO terms in NXF1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006405RNA export from nucleus
BPIDAGO:0006406mRNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPIEAGO:0016032viral process
BPIBAGO:0016973poly(A)+ mRNA export from nucleus
CCIDAGO:0000346transcription export complex
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIEAGO:0005643nuclear pore
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0016607nuclear speck
CCIEAGO:0042405nuclear inclusion body
MFHDAGO:0003723RNA binding
MFIEAGO:0003729mRNA binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: NXF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NXF1


DatabasePathway IDPathway Des.
wikipathwaysWP411mRNA Processing
kegghsa03008Ribosome biogenesis in eukaryotes - Homo sapiens (human)
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa03015mRNA surveillance pathway - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
reactomeR-HSA-159227Transport of the SLBP independent Mature mRNA
reactomeR-HSA-159230Transport of the SLBP Dependant Mature mRNA
reactomeR-HSA-159231Transport of Mature mRNA Derived from an Intronless Transcript
reactomeR-HSA-159234Transport of Mature mRNAs Derived from Intronless Transcripts
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NXF1

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