OGDHL


Summary: The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. [provided by RefSeq, Dec 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
oxoglutarate dehydrogenase likeMIM:617513Ensembl:ENSG00000197444HGNC:HGNC:25590PA13487890710q11.23

GO terms in OGDHL


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006096glycolytic process
BPIBAGO:0006099tricarboxylic acid cycle
CCIBAGO:0005739mitochondrion
CCIEAGO:0005759mitochondrial matrix
CCIBAGO:0005829cytosol
CCIBAGO:0045252oxoglutarate dehydrogenase complex
MFIBAGO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity
MFIPIGO:0005515protein binding
MFIEAGO:0030976thiamine pyrophosphate binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: OGDHL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OGDHL


DatabasePathway IDPathway Des.
kegghsa00020Citrate cycle (TCA cycle) - Homo sapiens (human)
kegghsa00310Lysine degradation - Homo sapiens (human)
kegghsa00380Tryptophan metabolism - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OGDHL

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