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OSGIN1

Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
oxidative stress induced growth inhibitor 1	MIM:607975	Ensembl:ENSG00000140961	HGNC:HGNC:30093	PA162398489	16q23.3

Gene Categories:

GROWTH FACTOR

GO terms in OSGIN1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0007275	multicellular organism development
BP	IEA	GO:0010469	regulation of signaling receptor activity
BP	IEA	GO:0030154	cell differentiation
BP	IBA	GO:0030308	negative regulation of cell growth
BP	IDA	GO:0030308	negative regulation of cell growth
BP	IEA	GO:0043065	positive regulation of apoptotic process
CC	ND	GO:0005575	cellular_component
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0008083	growth factor activity
MF	IDA	GO:0008083	growth factor activity

Gene expression in normal tissue: OSGIN1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OSGIN1

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OSGIN1

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DATATYPES

CLASSFICATION

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