OSGIN1


Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
oxidative stress induced growth inhibitor 1MIM:607975Ensembl:ENSG00000140961HGNC:HGNC:30093PA16239848916q23.3

Gene Categories:

GROWTH FACTOR

GO terms in OSGIN1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007275multicellular organism development
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0030154cell differentiation
BPIBAGO:0030308negative regulation of cell growth
BPIDAGO:0030308negative regulation of cell growth
BPIEAGO:0043065positive regulation of apoptotic process
CCNDGO:0005575cellular_component
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIDAGO:0008083growth factor activity

Gene expression in normal tissue: OSGIN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OSGIN1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OSGIN1

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