PACSIN3
Summary: This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C and casein kinase substrate in neurons 3 | MIM:606513 | Ensembl:ENSG00000165912 | HGNC:HGNC:8572 | PA32898 | 11p11.2 |
GO terms in PACSIN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006897 | endocytosis |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | IBA | GO:0030100 | regulation of endocytosis |
| BP | ISS | GO:0045806 | negative regulation of endocytosis |
| BP | IMP | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| BP | ISS | GO:0051926 | negative regulation of calcium ion transport |
| BP | IBA | GO:0097320 | plasma membrane tubulation |
| BP | IDA | GO:0097320 | plasma membrane tubulation |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005768 | endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005543 | phospholipid binding |
| MF | IBA | GO:0008092 | cytoskeletal protein binding |
| MF | ISS | GO:0008092 | cytoskeletal protein binding |
| MF | IDA | GO:0008289 | lipid binding |
| MF | ISS | GO:0019855 | calcium channel inhibitor activity |
Gene expression in normal tissue: PACSIN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PACSIN3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PACSIN3
CLASSFICATION
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