PACSIN3


Summary: This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase C and casein kinase substrate in neurons 3MIM:606513Ensembl:ENSG00000165912HGNC:HGNC:8572PA3289811p11.2

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in PACSIN3


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006897endocytosis
BPIBAGO:0007010cytoskeleton organization
BPIBAGO:0030100regulation of endocytosis
BPISSGO:0045806negative regulation of endocytosis
BPIMPGO:0051044positive regulation of membrane protein ectodomain proteolysis
BPISSGO:0051926negative regulation of calcium ion transport
BPIBAGO:0097320plasma membrane tubulation
BPIDAGO:0097320plasma membrane tubulation
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIBAGO:0005768endosome
CCIDAGO:0005829cytosol
CCIBAGO:0005856cytoskeleton
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCHDAGO:0070062extracellular exosome
MFIPIGO:0005515protein binding
MFIBAGO:0005543phospholipid binding
MFIBAGO:0008092cytoskeletal protein binding
MFISSGO:0008092cytoskeletal protein binding
MFIDAGO:0008289lipid binding
MFISSGO:0019855calcium channel inhibitor activity

Gene expression in normal tissue: PACSIN3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PACSIN3


DatabasePathway IDPathway Des.
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856828Clathrin-mediated endocytosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PACSIN3

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