PALM
Summary: This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
paralemmin | MIM:608134 | Ensembl:ENSG00000099864 | HGNC:HGNC:8594 | PA32923 | 19p13.3 |
GO terms in PALM
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0031750 | D3 dopamine receptor binding |
CC | IDA | GO:0005634 | nucleus |
CC | IBA | GO:0005886 | plasma membrane |
CC | IDA | GO:0005886 | plasma membrane |
CC | IEA | GO:0014069 | postsynaptic density |
CC | IEA | GO:0016323 | basolateral plasma membrane |
CC | IEA | GO:0016327 | apicolateral plasma membrane |
CC | IEA | GO:0030424 | axon |
CC | TAS | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane |
CC | TAS | GO:0031410 | cytoplasmic vesicle |
CC | IDA | GO:0031527 | filopodium membrane |
CC | IEA | GO:0032591 | dendritic spine membrane |
CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
BP | IEA | GO:0007010 | cytoskeleton organization |
BP | IEA | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
BP | IBA | GO:0007194 | negative regulation of adenylate cyclase activity |
BP | IDA | GO:0007194 | negative regulation of adenylate cyclase activity |
BP | IEA | GO:0008360 | regulation of cell shape |
BP | IBA | GO:0023052 | signaling |
BP | IBA | GO:0051491 | positive regulation of filopodium assembly |
BP | IDA | GO:0051491 | positive regulation of filopodium assembly |
BP | IEA | GO:0060074 | synapse maturation |
BP | IDA | GO:0060160 | negative regulation of dopamine receptor signaling pathway |
BP | IEA | GO:0071257 | cellular response to electrical stimulus |
BP | IEA | GO:0072659 | protein localization to plasma membrane |
Gene expression in normal tissue: PALM
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PALM
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PALM