PCDH12
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protocadherin 12 | MIM:605622 | Ensembl:ENSG00000113555 | HGNC:HGNC:8657 | PA32998 | 5q31.3 |
GO terms in PCDH12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0005977 | glycogen metabolic process |
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IBA | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0008038 | neuron recognition |
| BP | IEA | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IEA | GO:0060711 | labyrinthine layer development |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IEA | GO:0005509 | calcium ion binding |
Gene expression in normal tissue: PCDH12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCDH12
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCDH12
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