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PCDH8

Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
protocadherin 8	MIM:603580	Ensembl:ENSG00000136099	HGNC:HGNC:8660	PA33007	13q14.3

GO terms in PCDH8

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0005509	calcium ion binding
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	TAS	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0030054	cell junction
CC	IEA	GO:0030425	dendrite
CC	IEA	GO:0042734	presynaptic membrane
CC	IEA	GO:0045211	postsynaptic membrane
BP	IEA	GO:0001756	somitogenesis
BP	IBA	GO:0007155	cell adhesion
BP	IEA	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
BP	IBA	GO:0007267	cell-cell signaling
BP	TAS	GO:0007267	cell-cell signaling
BP	IEA	GO:0007268	chemical synaptic transmission
BP	IEA	GO:0016331	morphogenesis of embryonic epithelium

Gene expression in normal tissue: PCDH8

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PCDH8

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCDH8

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CLASSFICATION

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