PDCD4 Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
GO terms in PDCD4 Term Type Evidence Type GO Term ID GO Des. BP NAS GO:0006915 apoptotic process BP IDA GO:0007569 cell aging BP IDA GO:0030509 BMP signaling pathway BP TAS GO:0035722 interleukin-12-mediated signaling pathway BP IEA GO:0043066 negative regulation of apoptotic process BP ISS GO:0043508 negative regulation of JUN kinase activity BP NAS GO:0045786 negative regulation of cell cycle BP IDA GO:0045892 negative regulation of transcription, DNA-templated BP ISS GO:0045892 negative regulation of transcription, DNA-templated BP ISS GO:0050729 positive regulation of inflammatory response BP ISS GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development BP ISS GO:0071222 cellular response to lipopolysaccharide BP ISS GO:1900016 negative regulation of cytokine production involved in inflammatory response BP IMP GO:1901224 positive regulation of NIK/NF-kappaB signaling BP IMP GO:1904706 negative regulation of vascular smooth muscle cell proliferation BP IMP GO:1904761 negative regulation of myofibroblast differentiation BP IDA GO:1905064 negative regulation of vascular smooth muscle cell differentiation BP IMP GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process BP IMP GO:2000353 positive regulation of endothelial cell apoptotic process CC IBA GO:0005634 nucleus CC IMP GO:0005634 nucleus CC ISS GO:0005634 nucleus CC IMP GO:0005737 cytoplasm CC IBA GO:0005829 cytosol CC IDA GO:0005829 cytosol CC TAS GO:0005829 cytosol MF IEA GO:0003723 RNA binding MF IPI GO:0005515 protein binding
Gene expression in normal tissue: PDCD4
Select Project:
Transcriptome or Gene expression: PRJEB2445
Transcriptome or Gene expression: PRJEB4337
Transcriptome or Gene expression: PRJNA270632
Transcriptome or Gene expression: PRJNA280600
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Gene-model tissue-cancer distribution: Bubble Plot
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Gene-drug pathway distribution
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