PDE1A
Summary: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphodiesterase 1A | MIM:171890 | Ensembl:ENSG00000115252 | HGNC:HGNC:8774 | PA33122 | 2q32.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PDE1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity |
| MF | TAS | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0030553 | cGMP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | TAS | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
| MF | IEA | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0043025 | neuronal cell body |
| BP | IEA | GO:0006198 | cAMP catabolic process |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0034391 | regulation of smooth muscle cell apoptotic process |
| BP | IEA | GO:0046069 | cGMP catabolic process |
| BP | IEA | GO:0048660 | regulation of smooth muscle cell proliferation |
Gene expression in normal tissue: PDE1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDE1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04742 | Taste transduction - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111957 | Cam-PDE 1 activation |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418457 | cGMP effects |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDE1A
CLASSFICATION
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