PDE1A


Summary: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphodiesterase 1AMIM:171890Ensembl:ENSG00000115252HGNC:HGNC:8774PA331222q32.1

Gene Categories:

DRUGGABLE GENOME

GO terms in PDE1A


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:00041153',5'-cyclic-AMP phosphodiesterase activity
MFTASGO:0004117calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
MFIEAGO:0005516calmodulin binding
MFIEAGO:0030553cGMP binding
MFIEAGO:0046872metal ion binding
MFTASGO:00475553',5'-cyclic-GMP phosphodiesterase activity
MFIEAGO:0048101calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
CCIEAGO:0005634nucleus
CCTASGO:0005829cytosol
CCIEAGO:0043025neuronal cell body
BPIEAGO:0006198cAMP catabolic process
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0034391regulation of smooth muscle cell apoptotic process
BPIEAGO:0046069cGMP catabolic process
BPIEAGO:0048660regulation of smooth muscle cell proliferation

Gene expression in normal tissue: PDE1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDE1A


DatabasePathway IDPathway Des.
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa04742Taste transduction - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP4222Phosphodiesterases in neuronal function
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111957Cam-PDE 1 activation
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418457cGMP effects
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDE1A

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