PDIA5
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
protein disulfide isomerase family A member 5 | MIM:616942 | Ensembl:ENSG00000065485 | HGNC:HGNC:24811 | PA142671191 | 3q21.1 |
GO terms in PDIA5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0003756 | protein disulfide isomerase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0015037 | peptide disulfide oxidoreductase activity |
MF | TAS | GO:0016491 | oxidoreductase activity |
CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
BP | TAS | GO:0006457 | protein folding |
BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
BP | IEA | GO:0045454 | cell redox homeostasis |
BP | TAS | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: PDIA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDIA5
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
reactome | R-HSA-381070 | IRE1alpha activates chaperones |
reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
reactome | R-HSA-392499 | Metabolism of proteins |
wikipathways | WP3472 | XBP1(S) activates chaperone genes |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDIA5