PDIA5


Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein disulfide isomerase family A member 5MIM:616942Ensembl:ENSG00000065485HGNC:HGNC:24811PA1426711913q21.1

GO terms in PDIA5


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003756protein disulfide isomerase activity
MFIPIGO:0005515protein binding
MFIDAGO:0015037peptide disulfide oxidoreductase activity
MFTASGO:0016491oxidoreductase activity
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005789endoplasmic reticulum membrane
BPTASGO:0006457protein folding
BPTASGO:0036498IRE1-mediated unfolded protein response
BPIEAGO:0045454cell redox homeostasis
BPTASGO:0055114oxidation-reduction process

Gene expression in normal tissue: PDIA5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDIA5


DatabasePathway IDPathway Des.
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
wikipathwaysWP3472XBP1(S) activates chaperone genes

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDIA5

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