PDIA5
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein disulfide isomerase family A member 5 | MIM:616942 | Ensembl:ENSG00000065485 | HGNC:HGNC:24811 | PA142671191 | 3q21.1 |
GO terms in PDIA5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003756 | protein disulfide isomerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015037 | peptide disulfide oxidoreductase activity |
| MF | TAS | GO:0016491 | oxidoreductase activity |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| BP | TAS | GO:0006457 | protein folding |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | TAS | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: PDIA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDIA5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDIA5
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