PDZD2
Summary: The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PDZ domain containing 2 | MIM:610697 | Ensembl:ENSG00000133401 | HGNC:HGNC:18486 | PA33164 | 5p13.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PDZD2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007155 | cell adhesion |
| CC | ISS | GO:0005576 | extracellular region |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005911 | cell-cell junction |
Gene expression in normal tissue: PDZD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDZD2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDZD2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.