PHB2


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
prohibitin 2MIM:610704Ensembl:ENSG00000215021HGNC:HGNC:30306PA14267118112p13.31

GO terms in PHB2


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCHDAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCIDAGO:0005741mitochondrial outer membrane
CCISSGO:0005743mitochondrial inner membrane
CCTASGO:0005743mitochondrial inner membrane
CCIDAGO:0009986cell surface
CCIDAGO:0016363nuclear matrix
CCIEAGO:0030424axon
CCIDAGO:0032991protein-containing complex
CCIDAGO:0071944cell periphery
BPIDAGO:0000060protein import into nucleus, translocation
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0006851mitochondrial calcium ion transmembrane transport
BPIMPGO:0007005mitochondrion organization
BPIDAGO:0007062sister chromatid cohesion
BPIEAGO:0009611response to wounding
BPIDAGO:0030449regulation of complement activation
BPIMPGO:0031536positive regulation of exit from mitosis
BPIEAGO:0033147negative regulation of intracellular estrogen receptor signaling pathway
BPIEAGO:0033600negative regulation of mammary gland epithelial cell proliferation
BPIMPGO:0043066negative regulation of apoptotic process
BPIMPGO:0043433negative regulation of DNA-binding transcription factor activity
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0050821protein stabilization
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0060744mammary gland branching involved in thelarche
BPIEAGO:0060749mammary gland alveolus development
BPIEAGO:0060762regulation of branching involved in mammary gland duct morphogenesis
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPHEPGO:0071277cellular response to calcium ion
BPIEAGO:0071300cellular response to retinoic acid
BPIEAGO:0071456cellular response to hypoxia
BPIMPGO:1902808positive regulation of cell cycle G1/S phase transition
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFNASGO:0030331estrogen receptor binding
MFIPIGO:0033218amide binding
MFIPIGO:0047485protein N-terminus binding

Gene expression in normal tissue: PHB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PHB2


DatabasePathway IDPathway Des.
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-8949215Mitochondrial calcium ion transport
reactomeR-HSA-8949664Processing of SMDT1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PHB2

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