PHF21A
Summary: The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
PHD finger protein 21A | MIM:608325 | Ensembl:ENSG00000135365 | HGNC:HGNC:24156 | PA134977844 | 11p11.2 |
Gene Categories:
HISTONE MODIFICATIONGO terms in PHF21A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004407 | histone deacetylase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0046872 | metal ion binding |
CC | IBA | GO:0000118 | histone deacetylase complex |
CC | IDA | GO:0000118 | histone deacetylase complex |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:1990391 | DNA repair complex |
BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | TAS | GO:0007596 | blood coagulation |
BP | IEA | GO:0016575 | histone deacetylation |
Gene expression in normal tissue: PHF21A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHF21A
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-3214815 | HDACs deacetylate histones |
reactome | R-HSA-3247509 | Chromatin modifying enzymes |
reactome | R-HSA-4839726 | Chromatin organization |
reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PHF21A