PHLDA2
Summary: This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pleckstrin homology like domain family A member 2 | MIM:602131 | Ensembl:ENSG00000181649 | HGNC:HGNC:12385 | PA37053 | 11p15.4 |
Gene Categories:
HORMONE ACTIVITYGO terms in PHLDA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001890 | placenta development |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0030334 | regulation of cell migration |
| BP | IEA | GO:0060721 | regulation of spongiotrophoblast cell proliferation |
| BP | IEA | GO:0070873 | regulation of glycogen metabolic process |
| BP | IEA | GO:1903547 | regulation of growth hormone activity |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016020 | membrane |
Gene expression in normal tissue: PHLDA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHLDA2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PHLDA2
CLASSFICATION
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