PIAS2
Summary: This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein inhibitor of activated STAT 2 | MIM:603567 | Ensembl:ENSG00000078043 | HGNC:HGNC:17311 | PA134933292 | 18q21.1 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in PIAS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | EXP | GO:0019789 | SUMO transferase activity |
| MF | IEA | GO:0031625 | ubiquitin protein ligase binding |
| MF | NAS | GO:0050681 | androgen receptor binding |
| MF | IDA | GO:0061665 | SUMO ligase activity |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016605 | PML body |
| CC | IEA | GO:0016607 | nuclear speck |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0016925 | protein sumoylation |
| BP | IEA | GO:0016925 | protein sumoylation |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
| BP | IEA | GO:0045667 | regulation of osteoblast differentiation |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0060766 | negative regulation of androgen receptor signaling pathway |
Gene expression in normal tissue: PIAS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIAS2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ranbp2pathway | sumoylation by ranbp2 regulates transcriptional repression |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3232118 | SUMOylation of transcription factors |
| reactome | R-HSA-3232142 | SUMOylation of ubiquitinylation proteins |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | ranbp2pathway | Sumoylation by RanBP2 regulates transcriptional repression |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIAS2
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