PLA1A


Summary: The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phospholipase A1 member AMIM:607460Ensembl:ENSG00000144837HGNC:HGNC:17661PA1349558513q13.33

GO terms in PLA1A


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0008970phosphatidylcholine 1-acylhydrolase activity
MFTASGO:0052739phosphatidylserine 1-acylhydrolase activity
BPTASGO:0006629lipid metabolic process
BPTASGO:0006658phosphatidylserine metabolic process
BPIEAGO:0016042lipid catabolic process
BPTASGO:0036150phosphatidylserine acyl-chain remodeling
CCIEAGO:0002080acrosomal membrane
CCTASGO:0005576extracellular region

Gene expression in normal tissue: PLA1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLA1A


DatabasePathway IDPathway Des.
wikipathwaysWP4223Ras Signaling
kegghsa04014Ras signaling pathway - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1482801Acyl chain remodelling of PS
reactomeR-HSA-1483206Glycerophospholipid biosynthesis
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLA1A

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