PLA1A
Summary: The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipase A1 member A | MIM:607460 | Ensembl:ENSG00000144837 | HGNC:HGNC:17661 | PA134955851 | 3q13.33 |
GO terms in PLA1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity |
| MF | TAS | GO:0052739 | phosphatidylserine 1-acylhydrolase activity |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0006658 | phosphatidylserine metabolic process |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | TAS | GO:0036150 | phosphatidylserine acyl-chain remodeling |
| CC | IEA | GO:0002080 | acrosomal membrane |
| CC | TAS | GO:0005576 | extracellular region |
Gene expression in normal tissue: PLA1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLA1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4223 | Ras Signaling |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1482801 | Acyl chain remodelling of PS |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLA1A
CLASSFICATION
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