Summary: This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008].

plasminogen activator, urokinase receptorMIM:173391Ensembl:ENSG00000011422HGNC:HGNC:9053PA3338319q13.31

GO terms in PLAUR

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005576extracellular region
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCNASGO:0016021integral component of membrane
CCTASGO:0019898extrinsic component of membrane
CCIEAGO:0031225anchored component of membrane
CCTASGO:0035579specific granule membrane
CCIEAGO:0071438invadopodium membrane
BPIMPGO:0001934positive regulation of protein phosphorylation
BPTASGO:0007165signal transduction
BPNASGO:0007596blood coagulation
BPNASGO:0030162regulation of proteolysis
BPIMPGO:0043066negative regulation of apoptotic process
BPTASGO:0043312neutrophil degranulation
BPIDAGO:0043388positive regulation of DNA binding
BPIMPGO:0045742positive regulation of epidermal growth factor receptor signaling pathway
BPIMPGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIMPGO:2001243negative regulation of intrinsic apoptotic signaling pathway
BPIMPGO:2001268negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019904protein domain specific binding
MFIBAGO:0030377urokinase plasminogen activator receptor activity
MFNASGO:0030377urokinase plasminogen activator receptor activity
MFNASGO:0038023signaling receptor activity

Gene expression in normal tissue: PLAUR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLAUR

DatabasePathway IDPathway Des.
reactomeR-HSA-162791Attachment of GPI anchor to uPAR
reactomeR-HSA-163125Post-translational modification: synthesis of GPI-anchored proteins
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-75205Dissolution of Fibrin Clot
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
pidarf6downstreampathwayArf6 downstream pathway
pidfgf_pathwayFGF signaling pathway
pidfra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin2_pathwayBeta2 integrin cell surface interactions
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidintegrin5_pathwayBeta5 beta6 beta7 and beta8 integrin cell surface interactions
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2806Human Complement System
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP558Complement and Coagulation Cascades

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLAUR