PLEK2
Summary: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pleckstrin 2 | MIM:608007 | Ensembl:ENSG00000100558 | HGNC:HGNC:19238 | PA134963543 | 14q23.3-q24.1 |
GO terms in PLEK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0031346 | positive regulation of cell projection organization |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0031258 | lamellipodium membrane |
| MF | IEA | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding |
| MF | IEA | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding |
Gene expression in normal tissue: PLEK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLEK2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLEK2
CLASSFICATION
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