Summary: The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

phospholipid phosphatase 2MIM:607126Ensembl:ENSG00000141934HGNC:HGNC:9230PA3355419p13.3

Gene Categories:


GO terms in PLPP2

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004721phosphoprotein phosphatase activity
MFIPIGO:0005515protein binding
MFIBAGO:0008195phosphatidate phosphatase activity
MFIBAGO:0016791phosphatase activity
MFTASGO:0042392sphingosine-1-phosphate phosphatase activity
MFIBAGO:0042577lipid phosphatase activity
BPIEAGO:0006470protein dephosphorylation
BPIBAGO:0006644phospholipid metabolic process
BPIBAGO:0007165signal transduction
BPTASGO:0030148sphingolipid biosynthetic process
BPIBAGO:0046839phospholipid dephosphorylation
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane

Gene expression in normal tissue: PLPP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLPP2

DatabasePathway IDPathway Des.
smpdbSMP00039Glycerolipid Metabolism
smpdbSMP00187Glycerol Kinase Deficiency
smpdbSMP00529D-glyceric acidura
smpdbSMP00530Familial lipoprotein lipase deficiency
wikipathwaysWP325Triacylglyceride Synthesis
humancycTRIGLSYN-PWYtriacylglycerol biosynthesis
kegghsa00561Glycerolipid metabolism - Homo sapiens (human)
kegghsa00564Glycerophospholipid metabolism - Homo sapiens (human)
kegghsa00565Ether lipid metabolism - Homo sapiens (human)
kegghsa00600Sphingolipid metabolism - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04975Fat digestion and absorption - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
reactomeR-HSA-1660661Sphingolipid de novo biosynthesis
reactomeR-HSA-428157Sphingolipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLPP2