PLPP2
Summary: The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipid phosphatase 2 | MIM:607126 | Ensembl:ENSG00000141934 | HGNC:HGNC:9230 | PA33554 | 19p13.3 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PLPP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008195 | phosphatidate phosphatase activity |
| MF | IBA | GO:0016791 | phosphatase activity |
| MF | TAS | GO:0042392 | sphingosine-1-phosphate phosphatase activity |
| MF | IBA | GO:0042577 | lipid phosphatase activity |
| BP | IEA | GO:0006470 | protein dephosphorylation |
| BP | IBA | GO:0006644 | phospholipid metabolic process |
| BP | IBA | GO:0007165 | signal transduction |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IBA | GO:0046839 | phospholipid dephosphorylation |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
Gene expression in normal tissue: PLPP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLPP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00039 | Glycerolipid Metabolism |
| smpdb | SMP00187 | Glycerol Kinase Deficiency |
| smpdb | SMP00529 | D-glyceric acidura |
| smpdb | SMP00530 | Familial lipoprotein lipase deficiency |
| wikipathways | WP325 | Triacylglyceride Synthesis |
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| kegg | hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04975 | Fat digestion and absorption - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLPP2
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