Summary: The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

phospholipid phosphatase related 4MIM:607813Ensembl:ENSG00000117600HGNC:HGNC:234961p21.3-p21.2

GO terms in PLPPR4

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0008195phosphatidate phosphatase activity
MFTASGO:0008195phosphatidate phosphatase activity
MFIBAGO:0016791phosphatase activity
MFIBAGO:0042577lipid phosphatase activity
BPIBAGO:0006644phospholipid metabolic process
BPIBAGO:0007165signal transduction
BPIBAGO:0046839phospholipid dephosphorylation
BPIEAGO:0048839inner ear development
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane

Gene expression in normal tissue: PLPPR4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLPPR4

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-419408Lysosphingolipid and LPA receptors
reactomeR-HSA-500792GPCR ligand binding
humancycTRIGLSYN-PWYtriacylglycerol biosynthesis

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLPPR4