PLPPR4
Summary: The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipid phosphatase related 4 | MIM:607813 | Ensembl:ENSG00000117600 | HGNC:HGNC:23496 | 1p21.3-p21.2 |
GO terms in PLPPR4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0008195 | phosphatidate phosphatase activity |
| MF | TAS | GO:0008195 | phosphatidate phosphatase activity |
| MF | IBA | GO:0016791 | phosphatase activity |
| MF | IBA | GO:0042577 | lipid phosphatase activity |
| BP | IBA | GO:0006644 | phospholipid metabolic process |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007409 | axonogenesis |
| BP | IBA | GO:0046839 | phospholipid dephosphorylation |
| BP | IEA | GO:0048839 | inner ear development |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: PLPPR4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLPPR4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-419408 | Lysosphingolipid and LPA receptors |
| reactome | R-HSA-500792 | GPCR ligand binding |
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLPPR4
CLASSFICATION
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