POLA1


Summary: This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA polymerase alpha 1, catalytic subunitMIM:312040Ensembl:ENSG00000101868HGNC:HGNC:9173PA162399856Xp22.11-p21.3

GO terms in POLA1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIMPGO:0000731DNA synthesis involved in DNA repair
BPIMPGO:0006260DNA replication
BPIDAGO:0006269DNA replication, synthesis of RNA primer
BPIDAGO:0006270DNA replication initiation
BPIMPGO:0006271DNA strand elongation involved in DNA replication
BPIBAGO:0006272leading strand elongation
BPIDAGO:0006272leading strand elongation
BPIBAGO:0006273lagging strand elongation
BPIDAGO:0006273lagging strand elongation
BPIDAGO:0006281DNA repair
BPIMPGO:0006281DNA repair
BPIMPGO:0006289nucleotide-excision repair
BPIBAGO:0006303double-strand break repair via nonhomologous end joining
BPIMPGO:0006303double-strand break repair via nonhomologous end joining
BPIDAGO:0008283cell proliferation
BPIEAGO:0016032viral process
BPTASGO:0032201telomere maintenance via semi-conservative replication
BPIBAGO:1902975mitotic DNA replication initiation
BPIBAGO:1902981synthesis of RNA primer involved in mitotic DNA replication
BPIMPGO:1904161DNA synthesis involved in UV-damage excision repair
CCIDAGO:0000785chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005635nuclear envelope
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005658alpha DNA polymerase:primase complex
CCIDAGO:0005658alpha DNA polymerase:primase complex
CCTASGO:0005658alpha DNA polymerase:primase complex
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCIDAGO:0016363nuclear matrix
MFIDAGO:0000166nucleotide binding
MFIEAGO:0001882nucleoside binding
MFIDAGO:0003677DNA binding
MFNASGO:0003677DNA binding
MFIDAGO:0003682chromatin binding
MFIBAGO:0003688DNA replication origin binding
MFIDAGO:0003887DNA-directed DNA polymerase activity
MFIMPGO:0003887DNA-directed DNA polymerase activity
MFIPIGO:0005515protein binding
MFIBAGO:0017076purine nucleotide binding
MFIPIGO:0019901protein kinase binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0046982protein heterodimerization activity
MFIEAGO:00515394 iron, 4 sulfur cluster binding

Gene expression in normal tissue: POLA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POLA1


DatabasePathway IDPathway Des.
reactomeR-HSA-113501Inhibition of replication initiation of damaged DNA by RB1/E2F1
reactomeR-HSA-113510E2F mediated regulation of DNA replication
reactomeR-HSA-157579Telomere Maintenance
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174411Polymerase switching on the C-strand of the telomere
reactomeR-HSA-174417Telomere C-strand (Lagging Strand) Synthesis
reactomeR-HSA-174430Telomere C-strand synthesis initiation
reactomeR-HSA-180786Extension of Telomeres
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68952DNA replication initiation
reactomeR-HSA-68962Activation of the pre-replicative complex
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69091Polymerase switching
reactomeR-HSA-69109Leading Strand Synthesis
reactomeR-HSA-69166Removal of the Flap Intermediate
reactomeR-HSA-69183Processive synthesis on the lagging strand
reactomeR-HSA-69186Lagging Strand Synthesis
reactomeR-HSA-69190DNA strand elongation
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-73886Chromosome Maintenance
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP4022Pyrimidine metabolism
wikipathwaysWP404Nucleotide Metabolism
wikipathwaysWP466DNA Replication
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa03030DNA replication - Homo sapiens (human)
pide2f_pathwayE2F transcription factor network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POLA1

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