POLA2


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA polymerase alpha 2, accessory subunitEnsembl:ENSG00000014138HGNC:HGNC:30073PA41111q13.1

GO terms in POLA2


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIEAGO:0003677DNA binding
MFIEAGO:0003887DNA-directed DNA polymerase activity
MFIBAGO:0046982protein heterodimerization activity
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005658alpha DNA polymerase:primase complex
CCIDAGO:0005829cytosol
BPIEAGO:0000060protein import into nucleus, translocation
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPNASGO:0006260DNA replication
BPIBAGO:0006270DNA replication initiation
BPTASGO:0032201telomere maintenance via semi-conservative replication
BPIEAGO:0071897DNA biosynthetic process

Gene expression in normal tissue: POLA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POLA2


DatabasePathway IDPathway Des.
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa03030DNA replication - Homo sapiens (human)
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP4022Pyrimidine metabolism
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP466DNA Replication
reactomeR-HSA-113501Inhibition of replication initiation of damaged DNA by RB1/E2F1
reactomeR-HSA-113510E2F mediated regulation of DNA replication
reactomeR-HSA-157579Telomere Maintenance
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174411Polymerase switching on the C-strand of the telomere
reactomeR-HSA-174417Telomere C-strand (Lagging Strand) Synthesis
reactomeR-HSA-174430Telomere C-strand synthesis initiation
reactomeR-HSA-180786Extension of Telomeres
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68952DNA replication initiation
reactomeR-HSA-68962Activation of the pre-replicative complex
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69091Polymerase switching
reactomeR-HSA-69109Leading Strand Synthesis
reactomeR-HSA-69166Removal of the Flap Intermediate
reactomeR-HSA-69183Processive synthesis on the lagging strand
reactomeR-HSA-69186Lagging Strand Synthesis
reactomeR-HSA-69190DNA strand elongation
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-73886Chromosome Maintenance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POLA2

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