POLR2B
Summary: This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RNA polymerase II subunit B | MIM:180661 | Ensembl:ENSG00000047315 | HGNC:HGNC:9188 | PA33508 | 4q12 |
Gene Categories:
DNA REPAIRGO terms in POLR2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005665 | DNA-directed RNA polymerase II, core complex |
| CC | IDA | GO:0005665 | DNA-directed RNA polymerase II, core complex |
| CC | HDA | GO:0016020 | membrane |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | IDA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | TAS | GO:0006370 | 7-methylguanosine mRNA capping |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0016070 | RNA metabolic process |
| BP | TAS | GO:0042795 | snRNA transcription by RNA polymerase II |
| BP | TAS | GO:0060964 | regulation of gene silencing by miRNA |
| MF | IBA | GO:0001055 | RNA polymerase II activity |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003899 | DNA-directed 5'-3' RNA polymerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0032549 | ribonucleoside binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: POLR2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POLR2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-113418 | Formation of the Early Elongation Complex |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat |
| reactome | R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex |
| reactome | R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation |
| reactome | R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| reactome | R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-167287 | HIV elongation arrest and recovery |
| reactome | R-HSA-167290 | Pausing and recovery of HIV elongation |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168325 | Viral Messenger RNA Synthesis |
| reactome | R-HSA-1839126 | FGFR2 mutant receptor activation |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-203927 | MicroRNA (miRNA) biogenesis |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-6803529 | FGFR2 alternative splicing |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-72086 | mRNA Capping |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72165 | mRNA Splicing - Minor Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| reactome | R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE |
| reactome | R-HSA-8851708 | Signaling by FGFR2 IIIa TM |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa03020 | RNA polymerase - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| wikipathways | WP4022 | Pyrimidine metabolism |
| wikipathways | WP405 | Eukaryotic Transcription Initiation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POLR2B
CLASSFICATION
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