POLR2B


Summary: This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RNA polymerase II subunit BMIM:180661Ensembl:ENSG00000047315HGNC:HGNC:9188PA335084q12

Gene Categories:

DNA REPAIR

GO terms in POLR2B


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005665DNA-directed RNA polymerase II, core complex
CCIDAGO:0005665DNA-directed RNA polymerase II, core complex
CCHDAGO:0016020membrane
BPTASGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPIDAGO:0006366transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006368transcription elongation from RNA polymerase II promoter
BPTASGO:00063707-methylguanosine mRNA capping
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0016070RNA metabolic process
BPTASGO:0042795snRNA transcription by RNA polymerase II
BPTASGO:0060964regulation of gene silencing by miRNA
MFIBAGO:0001055RNA polymerase II activity
MFIEAGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFHDAGO:0003723RNA binding
MFIBAGO:0003899DNA-directed 5'-3' RNA polymerase activity
MFIPIGO:0005515protein binding
MFIEAGO:0032549ribonucleoside binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: POLR2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POLR2B


DatabasePathway IDPathway Des.
reactomeR-HSA-112382Formation of RNA Pol II elongation complex
reactomeR-HSA-113418Formation of the Early Elongation Complex
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643685Disease
reactomeR-HSA-167152Formation of HIV elongation complex in the absence of HIV Tat
reactomeR-HSA-167158Formation of the HIV-1 Early Elongation Complex
reactomeR-HSA-167160RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
reactomeR-HSA-167161HIV Transcription Initiation
reactomeR-HSA-167162RNA Polymerase II HIV Promoter Escape
reactomeR-HSA-167169HIV Transcription Elongation
reactomeR-HSA-167169HIV Transcription Elongation
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 Tat
reactomeR-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 Tat
reactomeR-HSA-167238Pausing and recovery of Tat-mediated HIV elongation
reactomeR-HSA-167242Abortive elongation of HIV-1 transcript in the absence of Tat
reactomeR-HSA-167243Tat-mediated HIV elongation arrest and recovery
reactomeR-HSA-167246Tat-mediated elongation of the HIV-1 transcript
reactomeR-HSA-167246Tat-mediated elongation of the HIV-1 transcript
reactomeR-HSA-167287HIV elongation arrest and recovery
reactomeR-HSA-167290Pausing and recovery of HIV elongation
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-168325Viral Messenger RNA Synthesis
reactomeR-HSA-1839126FGFR2 mutant receptor activation
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-203927MicroRNA (miRNA) biogenesis
reactomeR-HSA-211000Gene Silencing by RNA
reactomeR-HSA-211000Gene Silencing by RNA
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-452723Transcriptional regulation of pluripotent stem cells
reactomeR-HSA-5578749Transcriptional regulation by small RNAs
reactomeR-HSA-5601884PIWI-interacting RNA (piRNA) biogenesis
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-674695RNA Polymerase II Pre-transcription Events
reactomeR-HSA-6781823Formation of TC-NER Pre-Incision Complex
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782135Dual incision in TC-NER
reactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NER
reactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair Genes
reactomeR-HSA-6803529FGFR2 alternative splicing
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-72086mRNA Capping
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72165mRNA Splicing - Minor Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73776RNA Polymerase II Promoter Escape
reactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75953RNA Polymerase II Transcription Initiation
reactomeR-HSA-75955RNA Polymerase II Transcription Elongation
reactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter Clearance
reactomeR-HSA-77075RNA Pol II CTD phosphorylation and interaction with CE
reactomeR-HSA-8851708Signaling by FGFR2 IIIa TM
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9018519Estrogen-dependent gene expression
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa03020RNA polymerase - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
wikipathwaysWP4022Pyrimidine metabolism
wikipathwaysWP405Eukaryotic Transcription Initiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD662JQ-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POLR2B

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