POLR2F
Summary: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RNA polymerase II subunit F | MIM:604414 | Ensembl:ENSG00000100142 | HGNC:HGNC:9193 | PA33513 | 22q13.1 |
Gene Categories:
DNA REPAIRGO terms in POLR2F
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001054 | RNA polymerase I activity |
| MF | IBA | GO:0001055 | RNA polymerase II activity |
| MF | IBA | GO:0001056 | RNA polymerase III activity |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003899 | DNA-directed 5'-3' RNA polymerase activity |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | TAS | GO:0006361 | transcription initiation from RNA polymerase I promoter |
| BP | TAS | GO:0006363 | termination of RNA polymerase I transcription |
| BP | IDA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | TAS | GO:0006370 | 7-methylguanosine mRNA capping |
| BP | IEA | GO:0006383 | transcription by RNA polymerase III |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0016070 | RNA metabolic process |
| BP | TAS | GO:0042795 | snRNA transcription by RNA polymerase II |
| BP | TAS | GO:0045815 | positive regulation of gene expression, epigenetic |
| BP | TAS | GO:0060964 | regulation of gene silencing by miRNA |
| CC | IBA | GO:0000428 | DNA-directed RNA polymerase complex |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005665 | DNA-directed RNA polymerase II, core complex |
| CC | IDA | GO:0005665 | DNA-directed RNA polymerase II, core complex |
| CC | IBA | GO:0005666 | DNA-directed RNA polymerase III complex |
| CC | IBA | GO:0005736 | DNA-directed RNA polymerase I complex |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: POLR2F
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POLR2F
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP405 | Eukaryotic Transcription Initiation |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa03020 | RNA polymerase - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-113418 | Formation of the Early Elongation Complex |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat |
| reactome | R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex |
| reactome | R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation |
| reactome | R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| reactome | R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-167287 | HIV elongation arrest and recovery |
| reactome | R-HSA-167290 | Pausing and recovery of HIV elongation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168325 | Viral Messenger RNA Synthesis |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-1839126 | FGFR2 mutant receptor activation |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-203927 | MicroRNA (miRNA) biogenesis |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250924 | B-WICH complex positively regulates rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-6803529 | FGFR2 alternative splicing |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-72086 | mRNA Capping |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72165 | mRNA Splicing - Minor Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73772 | RNA Polymerase I Promoter Escape |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73777 | RNA Polymerase I Chain Elongation |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73780 | RNA Polymerase III Chain Elongation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73863 | RNA Polymerase I Transcription Termination |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73980 | RNA Polymerase III Transcription Termination |
| reactome | R-HSA-74158 | RNA Polymerase III Transcription |
| reactome | R-HSA-74158 | RNA Polymerase III Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| reactome | R-HSA-76046 | RNA Polymerase III Transcription Initiation |
| reactome | R-HSA-76046 | RNA Polymerase III Transcription Initiation |
| reactome | R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| reactome | R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| reactome | R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| reactome | R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| reactome | R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| reactome | R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| reactome | R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE |
| reactome | R-HSA-8851708 | Signaling by FGFR2 IIIa TM |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POLR2F
CLASSFICATION
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