PON2
Summary: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| paraoxonase 2 | MIM:602447 | Ensembl:ENSG00000105854 | HGNC:HGNC:9205 | PA33530 | 7q21.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PON2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004064 | arylesterase activity |
| MF | IBA | GO:0016788 | hydrolase activity, acting on ester bonds |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | TAS | GO:0102007 | acyl-L-homoserine-lactone lactonohydrolase activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005764 | lysosome |
| CC | IDA | GO:0005886 | plasma membrane |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IBA | GO:0009636 | response to toxic substance |
| BP | TAS | GO:0019372 | lipoxygenase pathway |
| BP | IDA | GO:0019439 | aromatic compound catabolic process |
Gene expression in normal tissue: PON2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PON2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| wikipathways | WP136 | Phase I biotransformations, non P450 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PON2
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