Summary: This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

POU class 6 homeobox 2MIM:609062Ensembl:ENSG00000106536HGNC:HGNC:21694PA1349694207p14.1

GO terms in POU6F2

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0007402ganglion mother cell fate determination
BPTASGO:0007417central nervous system development
BPTASGO:0007601visual perception
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity

Gene expression in normal tissue: POU6F2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POU6F2

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POU6F2