PPIB


Summary: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
peptidylprolyl isomerase BMIM:123841Ensembl:ENSG00000166794HGNC:HGNC:9255PA3358015q22.31

Gene Categories:

DRUGGABLE GENOME

GO terms in PPIB


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005783endoplasmic reticulum
CCNASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005788endoplasmic reticulum lumen
CCIBAGO:0005790smooth endoplasmic reticulum
CCIEAGO:0005790smooth endoplasmic reticulum
CCHDAGO:0005925focal adhesion
CCHDAGO:0016020membrane
CCISSGO:0032991protein-containing complex
CCIBAGO:0034663endoplasmic reticulum chaperone complex
CCIEAGO:0034663endoplasmic reticulum chaperone complex
CCIEAGO:0042470melanosome
CCIBAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
BPIDAGO:0000413protein peptidyl-prolyl isomerization
BPISSGO:0000413protein peptidyl-prolyl isomerization
BPIBAGO:0040018positive regulation of multicellular organism growth
BPIMPGO:0040018positive regulation of multicellular organism growth
BPIBAGO:0044794positive regulation by host of viral process
BPIMPGO:0044794positive regulation by host of viral process
BPIBAGO:0044829positive regulation by host of viral genome replication
BPIMPGO:0044829positive regulation by host of viral genome replication
BPIBAGO:0050821protein stabilization
BPIMPGO:0050821protein stabilization
BPIBAGO:0060348bone development
BPIMPGO:0060348bone development
BPIBAGO:0061077chaperone-mediated protein folding
BPIDAGO:0061077chaperone-mediated protein folding
BPIMPGO:0061077chaperone-mediated protein folding
BPIBAGO:1901873regulation of post-translational protein modification
BPIMPGO:1901873regulation of post-translational protein modification
MFHDAGO:0003723RNA binding
MFIBAGO:0003755peptidyl-prolyl cis-trans isomerase activity
MFIDAGO:0003755peptidyl-prolyl cis-trans isomerase activity
MFISSGO:0003755peptidyl-prolyl cis-trans isomerase activity
MFNASGO:0003755peptidyl-prolyl cis-trans isomerase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005518collagen binding
MFISSGO:0005518collagen binding
MFIDAGO:0016018cyclosporin A binding
MFISSGO:0044877protein-containing complex binding
MFIBAGO:0051082unfolded protein binding
MFTASGO:0051082unfolded protein binding
MFIPIGO:0070063RNA polymerase binding

Gene expression in normal tissue: PPIB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPIB


DatabasePathway IDPathway Des.
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-1650814Collagen biosynthesis and modifying enzymes
smpdbSMP00074Retinol Metabolism
smpdbSMP00086Ibuprofen Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00336Vitamin A Deficiency
smpdbSMP00406Morphine Action Pathway
smpdbSMP00433Irinotecan Action Pathway
smpdbSMP00442Etoposide Action Pathway
smpdbSMP00590Ibuprofen Metabolism Pathway
smpdbSMP00600Irinotecan Metabolism Pathway
smpdbSMP00601Etoposide Metabolism Pathway
smpdbSMP00622Morphine Metabolism Pathway
smpdbSMP00640Acetaminophen Metabolism Pathway
smpdbSMP00648Sorafenib Metabolism Pathway
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2037Prolactin Signaling Pathway
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
netpathPathway_ProlactinProlactin

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPIB

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