PPIL2
Summary: This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| peptidylprolyl isomerase like 2 | MIM:607588 | Ensembl:ENSG00000100023 | HGNC:HGNC:9261 | PA33588 | 22q11.21 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PPIL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | IDA | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016018 | cyclosporin A binding |
| MF | IBA | GO:0034450 | ubiquitin-ubiquitin ligase activity |
| MF | IDA | GO:0034450 | ubiquitin-ubiquitin ligase activity |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
| BP | IBA | GO:0000209 | protein polyubiquitination |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IBA | GO:0000413 | protein peptidyl-prolyl isomerization |
| BP | IEA | GO:0000413 | protein peptidyl-prolyl isomerization |
| BP | IEA | GO:0006457 | protein folding |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | IDA | GO:0005886 | plasma membrane |
Gene expression in normal tissue: PPIL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPIL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPIL2
CLASSFICATION
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