PPP1R15A
Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 1 regulatory subunit 15A | MIM:611048 | Ensembl:ENSG00000087074 | HGNC:HGNC:14375 | PA33632 | 19q13.33 |
GO terms in PPP1R15A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008157 | protein phosphatase 1 binding |
| MF | IPI | GO:0008157 | protein phosphatase 1 binding |
| MF | IBA | GO:0019888 | protein phosphatase regulator activity |
| MF | IC | GO:0019888 | protein phosphatase regulator activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IC | GO:0072542 | protein phosphatase activator activity |
| CC | IBA | GO:0000164 | protein phosphatase type 1 complex |
| CC | IDA | GO:0000164 | protein phosphatase type 1 complex |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | NAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016020 | membrane |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IC | GO:0032058 | positive regulation of translational initiation in response to stress |
| BP | IDA | GO:0032515 | negative regulation of phosphoprotein phosphatase activity |
| BP | IBA | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| BP | IDA | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| BP | IBA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IDA | GO:0035308 | negative regulation of protein dephosphorylation |
| BP | IDA | GO:0036496 | regulation of translational initiation by eIF2 alpha dephosphorylation |
| BP | TAS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IMP | GO:0070972 | protein localization to endoplasmic reticulum |
| BP | IDA | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation |
| BP | TAS | GO:1903898 | negative regulation of PERK-mediated unfolded protein response |
| BP | IDA | GO:1903917 | positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation |
| BP | TAS | GO:1903917 | positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation |
Gene expression in normal tissue: PPP1R15A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP1R15A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| pid | bmppathway | BMP receptor signaling |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP1R15A
CLASSFICATION
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