Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008].

protein phosphatase 1 regulatory subunit 15AMIM:611048Ensembl:ENSG00000087074HGNC:HGNC:14375PA3363219q13.33

GO terms in PPP1R15A

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0008157protein phosphatase 1 binding
MFIPIGO:0008157protein phosphatase 1 binding
MFIBAGO:0019888protein phosphatase regulator activity
MFICGO:0019888protein phosphatase regulator activity
MFIPIGO:0019901protein kinase binding
MFICGO:0072542protein phosphatase activator activity
CCIBAGO:0000164protein phosphatase type 1 complex
CCIDAGO:0000164protein phosphatase type 1 complex
CCIEAGO:0005741mitochondrial outer membrane
CCIBAGO:0005783endoplasmic reticulum
CCIDAGO:0005783endoplasmic reticulum
CCNASGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005794Golgi apparatus
BPTASGO:0006915apoptotic process
BPTASGO:0006974cellular response to DNA damage stimulus
BPTASGO:0007050cell cycle arrest
BPICGO:0032058positive regulation of translational initiation in response to stress
BPIDAGO:0032515negative regulation of phosphoprotein phosphatase activity
BPIBAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPIDAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPIBAGO:0034976response to endoplasmic reticulum stress
BPIDAGO:0034976response to endoplasmic reticulum stress
BPIDAGO:0035308negative regulation of protein dephosphorylation
BPIDAGO:0036496regulation of translational initiation by eIF2 alpha dephosphorylation
BPTASGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIMPGO:0070972protein localization to endoplasmic reticulum
BPIDAGO:1902310positive regulation of peptidyl-serine dephosphorylation
BPTASGO:1903898negative regulation of PERK-mediated unfolded protein response
BPIDAGO:1903917positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
BPTASGO:1903917positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

Gene expression in normal tissue: PPP1R15A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPP1R15A

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-9006936Signaling by TGF-beta family members
pidbmppathwayBMP receptor signaling
pidtgfbrpathwayTGF-beta receptor signaling
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD728FOLFIRI regimen1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP1R15A