PPP1R9A


Summary: This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein phosphatase 1 regulatory subunit 9AMIM:602468Ensembl:ENSG00000158528HGNC:HGNC:14946PA336617q21.3

Gene Categories:

KINASE

GO terms in PPP1R9A


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCIEAGO:0005829cytosol
CCIBAGO:0014069postsynaptic density
CCIEAGO:0014069postsynaptic density
CCIBAGO:0015629actin cytoskeleton
CCIEAGO:0030054cell junction
CCIEAGO:0030175filopodium
CCIBAGO:0030425dendrite
CCIEAGO:0030864cortical actin cytoskeleton
CCIEAGO:0031594neuromuscular junction
CCIEAGO:0043025neuronal cell body
CCIEAGO:0044326dendritic spine neck
CCIEAGO:1990761growth cone lamellipodium
BPIBAGO:0007015actin filament organization
BPIEAGO:0007015actin filament organization
BPIEAGO:0007568aging
BPIBAGO:0019722calcium-mediated signaling
BPIEAGO:0019722calcium-mediated signaling
BPIEAGO:0030833regulation of actin filament polymerization
BPIBAGO:0031175neuron projection development
BPIEAGO:0031175neuron projection development
BPIEAGO:0045860positive regulation of protein kinase activity
BPIEAGO:0051489regulation of filopodium assembly
BPIEAGO:0051497negative regulation of stress fiber assembly
BPIEAGO:0051823regulation of synapse structural plasticity
BPIEAGO:0051963regulation of synapse assembly
BPIEAGO:0060079excitatory postsynaptic potential
BPIEAGO:0060999positive regulation of dendritic spine development
BPIEAGO:0061001regulation of dendritic spine morphogenesis
BPIEAGO:0097237cellular response to toxic substance
BPIEAGO:1900272negative regulation of long-term synaptic potentiation
BPIEAGO:1900454positive regulation of long term synaptic depression
BPIEAGO:1904049negative regulation of spontaneous neurotransmitter secretion
MFIPIGO:0005515protein binding
MFIEAGO:0008022protein C-terminus binding
MFIEAGO:0008157protein phosphatase 1 binding
MFIEAGO:0019901protein kinase binding
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0044325ion channel binding
MFIBAGO:0051015actin filament binding
MFIEAGO:0051015actin filament binding
MFIEAGO:0051020GTPase binding

Gene expression in normal tissue: PPP1R9A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPP1R9A


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP1R9A

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