PPP1R9A
Summary: This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 1 regulatory subunit 9A | MIM:602468 | Ensembl:ENSG00000158528 | HGNC:HGNC:14946 | PA33661 | 7q21.3 |
Gene Categories:
KINASEGO terms in PPP1R9A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IBA | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030175 | filopodium |
| CC | IBA | GO:0030425 | dendrite |
| CC | IEA | GO:0030864 | cortical actin cytoskeleton |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0044326 | dendritic spine neck |
| CC | IEA | GO:1990761 | growth cone lamellipodium |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | IEA | GO:0007015 | actin filament organization |
| BP | IEA | GO:0007568 | aging |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0030833 | regulation of actin filament polymerization |
| BP | IBA | GO:0031175 | neuron projection development |
| BP | IEA | GO:0031175 | neuron projection development |
| BP | IEA | GO:0045860 | positive regulation of protein kinase activity |
| BP | IEA | GO:0051489 | regulation of filopodium assembly |
| BP | IEA | GO:0051497 | negative regulation of stress fiber assembly |
| BP | IEA | GO:0051823 | regulation of synapse structural plasticity |
| BP | IEA | GO:0051963 | regulation of synapse assembly |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:0060999 | positive regulation of dendritic spine development |
| BP | IEA | GO:0061001 | regulation of dendritic spine morphogenesis |
| BP | IEA | GO:0097237 | cellular response to toxic substance |
| BP | IEA | GO:1900272 | negative regulation of long-term synaptic potentiation |
| BP | IEA | GO:1900454 | positive regulation of long term synaptic depression |
| BP | IEA | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IEA | GO:0008157 | protein phosphatase 1 binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0044325 | ion channel binding |
| MF | IBA | GO:0051015 | actin filament binding |
| MF | IEA | GO:0051015 | actin filament binding |
| MF | IEA | GO:0051020 | GTPase binding |
Gene expression in normal tissue: PPP1R9A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP1R9A
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP1R9A
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