PPP2R1A


Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein phosphatase 2 scaffold subunit AalphaMIM:605983Ensembl:ENSG00000105568HGNC:HGNC:9302PA3366619q13.41

GO terms in PPP2R1A


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004722protein serine/threonine phosphatase activity
MFIEAGO:0004722protein serine/threonine phosphatase activity
MFIPIGO:0005515protein binding
MFIBAGO:0019888protein phosphatase regulator activity
MFTASGO:0019888protein phosphatase regulator activity
MFIPIGO:0046982protein heterodimerization activity
MFIPIGO:1990405protein antigen binding
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPNASGO:0000188inactivation of MAPK activity
BPNASGO:0006275regulation of DNA replication
BPNASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006470protein dephosphorylation
BPNASGO:0006672ceramide metabolic process
BPTASGO:0006915apoptotic process
BPIDAGO:0007059chromosome segregation
BPIEAGO:0007143female meiotic nuclear division
BPNASGO:0008380RNA splicing
BPNASGO:0010033response to organic substance
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPNASGO:0019932second-messenger-mediated signaling
BPNASGO:0030111regulation of Wnt signaling pathway
BPNASGO:0030155regulation of cell adhesion
BPNASGO:0030308negative regulation of cell growth
BPNASGO:0040008regulation of growth
BPNASGO:0042532negative regulation of tyrosine phosphorylation of STAT protein
BPIEAGO:0043666regulation of phosphoprotein phosphatase activity
BPNASGO:0045595regulation of cell differentiation
BPIEAGO:0051232meiotic spindle elongation
BPIEAGO:0051306mitotic sister chromatid separation
BPIEAGO:0051754meiotic sister chromatid cohesion, centromeric
BPTASGO:0065003protein-containing complex assembly
BPIEAGO:0070262peptidyl-serine dephosphorylation
BPTASGO:0097711ciliary basal body-plasma membrane docking
BPIEAGO:1903538regulation of meiotic cell cycle process involved in oocyte maturation
BPIEAGO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
CCIBAGO:0000159protein phosphatase type 2A complex
CCIDAGO:0000159protein phosphatase type 2A complex
CCTASGO:0000159protein phosphatase type 2A complex
CCIDAGO:0000775chromosome, centromeric region
CCNASGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCNASGO:0005739mitochondrion
CCTASGO:0005829cytosol
CCIBAGO:0008287protein serine/threonine phosphatase complex
CCNASGO:0015630microtubule cytoskeleton
CCNASGO:0016020membrane
CCIEAGO:0016328lateral plasma membrane
CCIEAGO:0030425dendrite
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: PPP2R1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPP2R1A


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-113501Inhibition of replication initiation of damaged DNA by RB1/E2F1
reactomeR-HSA-113510E2F mediated regulation of DNA replication
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1295596Spry regulation of FGF signaling
reactomeR-HSA-141424Amplification of signal from the kinetochores
reactomeR-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163767PP2A-mediated dephosphorylation of key metabolic factors
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-180024DARPP-32 events
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-196299Beta-catenin phosphorylation cascade
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-202670ERKs are inactivated
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2465910MASTL Facilitates Mitotic Progression
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2500257Resolution of Sister Chromatid Cohesion
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-2995383Initiation of Nuclear Envelope Reformation
reactomeR-HSA-2995410Nuclear Envelope Reassembly
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389513CTLA4 inhibitory signaling
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-432142Platelet sensitization by LDL
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-4839735AXIN mutants destabilize the destruction complex, activating WNT signaling
reactomeR-HSA-4839743phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
reactomeR-HSA-4839744truncated APC mutants destabilize the destruction complex
reactomeR-HSA-4839748AMER1 mutants destabilize the destruction complex
reactomeR-HSA-5339716Misspliced GSK3beta mutants stabilize beta-catenin
reactomeR-HSA-5358747S33 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358749S37 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358751S45 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358752T41 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5467337APC truncation mutants have impaired AXIN binding
reactomeR-HSA-5467340AXIN missense mutants destabilize the destruction complex
reactomeR-HSA-5467348Truncations of AMER1 destabilize the destruction complex
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654732Negative regulation of FGFR3 signaling
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663220RHO GTPases Activate Formins
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69618Mitotic Spindle Checkpoint
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-70171Glycolysis
reactomeR-HSA-70326Glucose metabolism
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8854518AURKA Activation by TPX2
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP500Glycogen Metabolism
kegghsa03015mRNA surveillance pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
pidatr_pathwayATR signaling pathway
piderbb1_downstream_pathwayErbB1 downstream signaling
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidplk1_pathwayPLK1 signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD378ZM-4474391
iGMDRD659Avagacestat (BMS-708163)1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP2R1A

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