PPP2R3B
Summary: Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 2 regulatory subunit B''beta | MIM:300339 | Ensembl:ENSG00000167393 | HGNC:HGNC:13417 | PA134878872 | Xp22.33 and Yp11.31 |
GO terms in PPP2R3B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006470 | protein dephosphorylation |
| BP | ISS | GO:0006470 | protein dephosphorylation |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
| CC | IBA | GO:0000159 | protein phosphatase type 2A complex |
| CC | ISS | GO:0000159 | protein phosphatase type 2A complex |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| MF | TAS | GO:0004721 | phosphoprotein phosphatase activity |
| MF | ISS | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0019888 | protein phosphatase regulator activity |
| MF | TAS | GO:0019888 | protein phosphatase regulator activity |
Gene expression in normal tissue: PPP2R3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP2R3B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| reactome | R-HSA-113510 | E2F mediated regulation of DNA replication |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| kegg | hsa03015 | mRNA surveillance pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP500 | Glycogen Metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP2R3B
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