PRAM1
Summary: The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PML-RARA regulated adaptor molecule 1 | MIM:606466 | Ensembl:ENSG00000133246 | HGNC:HGNC:30091 | PA142671137 | 19p13.2 |
GO terms in PRAM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007165 | signal transduction |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IPI | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: PRAM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRAM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | pmlpathway | regulation of transcriptional activity by pml |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRAM1
CLASSFICATION
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