PRDM2


Summary: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PR/SET domain 2MIM:601196Ensembl:ENSG00000116731HGNC:HGNC:9347PA337151p36.21

GO terms in PRDM2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIMPGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIMPGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFNASGO:0003700DNA-binding transcription factor activity
MFNASGO:0008270zinc ion binding
MFIEAGO:0018024histone-lysine N-methyltransferase activity
MFIBAGO:0031490chromatin DNA binding
MFIBAGO:0043565sequence-specific DNA binding
BPNASGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0008340determination of adult lifespan
BPIEAGO:0034968histone lysine methylation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005794Golgi apparatus

Gene expression in normal tissue: PRDM2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRDM2


DatabasePathway IDPathway Des.
kegghsa00310Lysine degradation - Homo sapiens (human)
wikipathwaysWP2369Histone Modifications

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDM2

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