PRDM8


Summary: This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PR/SET domain 8MIM:616639Ensembl:ENSG00000152784HGNC:HGNC:13993PA337204q21.21

Gene Categories:

METHYL TRANSFERASE

GO terms in PRDM8


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIBAGO:0014003oligodendrocyte development
BPIEAGO:0032259methylation
CCIDAGO:0005634nucleus
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0008168methyltransferase activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: PRDM8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRDM8


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDM8

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