PRDX1


Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
peroxiredoxin 1MIM:176763Ensembl:ENSG00000117450HGNC:HGNC:9352PA337221p34.1

GO terms in PRDX1


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIDAGO:0004601peroxidase activity
MFTASGO:0004601peroxidase activity
MFIPIGO:0005515protein binding
MFEXPGO:0008379thioredoxin peroxidase activity
MFIBAGO:0008379thioredoxin peroxidase activity
MFIDAGO:0008379thioredoxin peroxidase activity
MFIEAGO:0042802identical protein binding
MFHDAGO:0045296cadherin binding
CCHDAGO:0005615extracellular space
CCHDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0042470melanosome
CCIEAGO:0043209myelin sheath
CCHDAGO:0070062extracellular exosome
BPTASGO:0001501skeletal system development
BPHEPGO:0001895retina homeostasis
BPIBAGO:0006979response to oxidative stress
BPIEAGO:0008283cell proliferation
BPIEAGO:0019430removal of superoxide radicals
BPIDAGO:0030101natural killer cell activation
BPIEAGO:0032872regulation of stress-activated MAPK cascade
BPIEAGO:0034101erythrocyte homeostasis
BPTASGO:0034599cellular response to oxidative stress
BPIEAGO:0042267natural killer cell mediated cytotoxicity
BPIBAGO:0042744hydrogen peroxide catabolic process
BPIDAGO:0042744hydrogen peroxide catabolic process
BPIBAGO:0045454cell redox homeostasis
BPIEAGO:0045454cell redox homeostasis
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:1901222regulation of NIK/NF-kappaB signaling

Gene expression in normal tissue: PRDX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRDX1


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3299685Detoxification of Reactive Oxygen Species
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
reactomeR-HSA-8863678Neurodegenerative Diseases
reactomeR-HSA-8953897Cellular responses to external stimuli
pidar_pathwayCoregulation of Androgen receptor activity
netpathPathway_AndrogenReceptorAndrogenReceptor
kegghsa04146Peroxisome - Homo sapiens (human)
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDX1

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